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KMID : 0578320100290040349
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Molecules and Cells
2010 Volume.29 No. 4 p.349 ~ p.354
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Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide
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Lee Byung-Ryong
Lee Yeom-Pyo
Kim Dae-Won
Song Ha-Yong
Yoo Ki-Yeon
Won Moo-Ho
Kang Tae-Cheon
Lee Kwang-Jae
Kim Kyung-Hee
Joo Jin-Ho
Ham Hun-Ju
Hur Jang-Hyun
Cho Sung-Woo
Han Kyu-Hyung
Park Jin-Seu
Eum Won-Sik
Choi Soo-Young
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Abstract
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The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic β-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic β-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.
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KEYWORD
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Agrocybe chaxingu, blood glucose, nitric oxide (NO), polysaccharide
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