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KMID : 0578320100290040355
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Molecules and Cells
2010 Volume.29 No. 4 p.355 ~ p.361
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Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation
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Markus Plate
Ting Li
Yu Wang
Xiaoning Mo
Yingmei Zhang
Dalong Ma
Wenling Han
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Abstract
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Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.
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KEYWORD
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apoptosis, cell cycle, cell growth, CMTM4, MARVEL
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