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KMID : 0578320100290060581
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Molecules and Cells
2010 Volume.29 No. 6 p.581 ~ p.584
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Anti-Candida Property of a Lignan Glycoside Derived from Styrax japonica S. et Z. via Membrane-Active Mechanisms
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Cana Park
Woo Eun-Rhan
Lee Dong-Gun
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Abstract
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Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.
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KEYWORD
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anti-candida property, membrane-active mechanism, Styraxjaponoside C
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