|
KMID : 0578320100300010029
|
|
Molecules and Cells
2010 Volume.30 No. 1 p.29 ~ p.36
|
|
|
Dietary Hempseed Meal Intake Increases Body Growth and Shortens the Larval Stage via the Upregulation of Cell Growth and Sterol Lev-els in Drosophila melanogaster
|
|
Lee Min-Jung
Park Min-Soo
Hwang Soo-Jin
Hong Yoon-Ki
Choi Ga-Hee
Suh Yoon-Seak
Han Seung-Yeop
Kim Da-Rae
Jeun Jung-Ae
Oh Chun-Taek
Lee Sung-Joon
Han Sung-Jun
Kim Dong-Hak
Kim Eun-Soo
Jeong Gil-Sang
Cho Kyoung-Sang
|
|
|
Abstract
|
|
|
|
Hempseed, a rich source of polyunsaturated fatty acids (PUFAs) and phytosterols, has been recognized as a po-tential therapeutic food used for cardioprotection, preventing platelet aggregation, and improving atopic dermatitis. Although several studies have revealed the physiological benefits of hempseed on a variety of animals, the effects of dietary hempseed intake on animal development are currently unknown. In this study, we evaluated the developmental effects of the addition of hempseed meal (HSM) to the diet of Drosophila. Interestingly, dietary HSM intake was shown to increase the body size of flies by increasing cell numbers, and also truncated the larval period without affecting survival rate or longevity. The oviposition of female flies was also increased by dietary HSM supplementation. Interestingly, the levels of sterols, which are precursors of ecdysone, a molting hormone, were found to be elevated in the larvae fed on HSM. Additionally, the hexane extracts of hemp-seed mimicked the effects of HSM on growth, developmental timing, and reproduction. Moreover, among the major nonpolar components of HSM, feeding on cholesterol but not PUFA mix or campesterol acceler-ated pupariation and increased body size. These results indicate that the dietary intake of HSM accelerates both body growth and developmental rates in Drosophila via the stimulation of cell growth and ecdysone synthesis. Additionally, nonpolar components of hempseed, such as cholesterol, might be responsible for the effects of HSM on development and reproduction.
|
|
|
KEYWORD
|
|
|
body growth, cholesterol, developmental rate, Drosophila, ecdysone, hempseed meal, reproduction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|