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KMID : 0578320100300030255
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Molecules and Cells
2010 Volume.30 No. 3 p.255 ~ p.262
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Calcineurin Regulates Coelomocyte Endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans
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Song Hyun-Ok
Lee Jung-Soo
Ji Yon-Ju
Meenakshi Dwivedi
Cho Jeong-Hoon
Park Byung-Jae
Ahnn Joo-Hong
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Abstract
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C. elegans coelomocytes are macrophage-like scavenger cells that provide an excellent in vivo system for the study of clathrin-mediated endocytosis. Using this in vivo system, several genes involved in coelomocyte endocytosis have been identified previously. However, the detailed mechanism of endocytic pathway is still unknown. Here, we report a new function of calcineurin, an evolutionarily conserved Ca2+/calmodulin-dependent Ser/Thr protein phos- phatase, in coelomocyte endocytosis. We found that calcineurin mutants show defective coelomocyte endocytosis. Genetic analysis suggests that calcineurin and a GTPase, dynamin (DYN-1), may function upstream of an orphan receptor, CUP-4, to regulate endocytosis. Therefore, we propose a model in which calcineurin may regulate coelomocyte endocytosis via DYN-1 and CUP-4 in C. elegans.
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KEYWORD
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Ca2+ signaling, C. elegans, endocytosis, phosphatase
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