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KMID : 0578320100300030263
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Molecules and Cells
2010 Volume.30 No. 3 p.263 ~ p.270
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MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells
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Shin Hee-Sung
Yoo In-Hwa
Kim Yong-Jae
Lee Ji-Yun
Kim Hyong-Bai
Shouguang Jin
Ha Un-Hwan
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Abstract
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Epithelial cells act as the first line of host defense against microbes by producing a range of different mole-cules for clearance. Chemokines facilitate the clearance of invaders through the recruitment of leukocytes. Thus, upregulation of chemokine expression represents an important innate host defense response against invading microbes such as Streptococcus pneumoniae. In this study, we report that the expression of Monocyte Chemotactic Protein 1 (MCP1) was highly induced in response to S. pneumoniae in vitro and in vivo. Among numerous virulence factors, pneumococcal pneumolysin was found to be the major factor responsible for this induction. Furthermore, MCP1 induction was mediated by the p38 mitogen-activated protein kinase (MAPK) whose activation was controlled by MAPK phosphatase 1 (MKP1). Therefore, this study reveals novel roles of pneumolysin in mediating MKP1 expression for the reg-ulation of MCP1 expression in human epithelial cells.
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KEYWORD
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MCP1, MKP1, p38, pneumolysin, Streptococcus pneumoniae
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