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KMID : 0578320100300050455
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Molecules and Cells
2010 Volume.30 No. 5 p.455 ~ p.460
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Propofol Protects the Autophagic Cell Death Induced by the Ischemia/Reperfusion Injury in Rats
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Noh Hae-Sook
Shin Il-Woo
Ha Ji-Hye
Hah Young-Sool
Baek Seon-Mi
Kim Deok-Ryong
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Abstract
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Autophagy has been implicated in cardiac cell death dur-ing ischemia/reperfusion (I/R). In this study we investi-gated how propofol, an antioxidant widely used for anes-thesia, affects the autophagic cell death induced by the myocardial I/R injury. The infarction size in the myocar-dium was dramatically reduced in rats treated with propofol during I/R compared with untreated rats. A large number of autophagic vacuoles were observed in the cardiomyocytes of I/R-injured rats but rarely in I/R-injured rats treated with propofol. While LC3-II formation, an autophagy marker, was up-regulated in the I/R-injured myocardium, it was significantly down-regulated in the myocardial tissues of I/R-injured and propofol-treated rats. Moreover, propofol inhibited the I/R-induced expression of Beclin-1, and it accelerated phosphorylation of mTOR during I/R and Beclin-1/Bcl-2 interaction in cells, which indicates that it facilitates the inhibitory pathway of autophagy. These data suggest that propofol protects the autophagic cell death induced by the myocardial I/R injury.
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KEYWORD
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autophagy, Beclin-1/Bcl-2 interaction, cell death, ischemia/reperfusion, propofol
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