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KMID : 0578320110310050423
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Molecules and Cells
2011 Volume.31 No. 5 p.423 ~ p.429
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Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence
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Yun Jong-Seok
Pahk Jung-Woon
Lee Jong-Seok
Shin Won-Cheol
Lee Shin-Young
Hong Eock-Kee
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Abstract
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In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senes-cence.
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KEYWORD
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antioxidant, apoptosis, Inonotus obliquus, reactive oxygen species (ROS), stress-induced premature senescence
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