|
KMID : 0578320110310060547
|
|
Molecules and Cells
2011 Volume.31 No. 6 p.547 ~ p.552
|
|
|
Mapping Signals That Are Important for Nuclear and Nucleolar Localization in MCRS2
|
|
Chung-Wen Kuo
Wen-Hung Wang
Shih-Tung Liu
|
|
|
Abstract
|
|
|
|
MCRS2 is an oncoprotein that is sequestered in the nu-cleolus. When in the nucleolus, it promotes the transcrip-tion of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situ-ated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are impor-tant to understand the function of MCRS2.
|
|
|
KEYWORD
|
|
|
MCRS2, nucleolus, nucleolar localization
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|