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KMID : 0578320110310060563
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Molecules and Cells
2011 Volume.31 No. 6 p.563 ~ p.571
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Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes
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Lee Do-Hee
Lee You-Ra
Ryu Joo-Hyun
Park Sung-Goo
Cho Sa-Yeon
Lee Je-Jung
Choi Chan
Park Byoung-Chul
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Abstract
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In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, uro-kinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
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KEYWORD
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AAT, AGR2, DBP, gastric cancer, metastasis, proteome
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