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KMID : 0578320110320010015
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Molecules and Cells
2011 Volume.32 No. 1 p.15 ~ p.19
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A Large Population Genetic Study of 15 Autosomal Short Tandem Repeat Loci for Establishment of Korean DNA Profile Database
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Yoo Seong-Yeon
Cho Nam-Soo
Park Myung-Jin
Seong Ki-Min
Hwang Jung-Ho
Song Seok-Bean
Han Myun-Soo
Lee Won-Tae
Chung Ki-Wha
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Abstract
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Genotyping of highly polymorphic short tandem repeat (STR) markers is widely used for the genetic identification of individuals in forensic DNA analyses and in paternity disputes. The National DNA Profile Databank recently esta-blished by the DNA Identification Act in Korea contains the computerized STR DNA profiles of individuals convicted of crimes. For the establishment of a large autosomal STR loci population database, 1805 samples were obtained at random from Korean individuals and 15 autosomal STR markers were analyzed using the AmpFlSTR Identifiler PCR Amplification kit. For the 15 autosomal STR markers, no deviations from the Hardy-Weinberg equilibrium were observed. The most informative locus in our data set was the D2S1338 with a discrimination power of 0.9699. The combined matching probability was 1.521 x 10-17. This large STR profile dataset including atypical alleles will be impor-tant for the establishment of the Korean DNA database and for forensic applications.
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KEYWORD
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autosomal STRs, DNA profile data bank, Korean, microvariant, population database
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