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KMID : 0578320110320020161
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Molecules and Cells
2011 Volume.32 No. 2 p.161 ~ p.165
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Regulation of Notch1 Signaling by Delta-like Ligand 1 Intracellular Domain through Physical Interaction
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Jung Jane
Mo Jung-Soon
Kim Mi-Yeon
Ann Eun-Jung
Yoon Ji-Hye
Park Hee-Sae
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Abstract
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Notch signaling involves the proteolytic cleavage of the transmembrane Notch receptor after binding to its trans-membrane ligands. The Delta-like ligand 1 also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. In this study, we have demonstrated that the Delta-like 1 intracellular domain (Dll1-IC) specifically binds to Notch1-IC in the nucleus, thereby disrupting the association of the Notch1-IC-RBP-Jk-MAM transcription activator complex. Additionally, the Notch1-mediated blockage of the induction of MyoD is abolished by the co-expression of Dll1-IC. Collectively, our results show that Dll1-IC functions as a negative regulator in Notch signaling via the disruption of the Notch1-IC-RBP-Jk complex.
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KEYWORD
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Dll1-IC, MAML, MyoD, Notch1-IC
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