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KMID : 0578320110320030265
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Molecules and Cells
2011 Volume.32 No. 3 p.265 ~ p.272
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IL-15-Induced IL-10 Increases the Cytolytic Activity of Human Natural Killer Cells
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Park Ju-Yeong
Lee Suk-Hyung
Yoon Suk-Ran
Park Young-Jun
Jung Hai-Young
Kim Tae-Don
Choi In-Pyo
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Abstract
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Interleukin 10 (IL-10) is a multifunctional cytokine that regulates diverse functions of immune cells. Natural killer (NK) cells express the IL-10 and IL-10 receptor, but little is known about the function of IL-10 on NK cell activa-tion. In this study, we show the expression and role of IL-10 in human NK cells. Among the cytokines tested, IL-15 was the most potent inducer of IL-10, with a maximal peak expression at 5 h after treatment. Furthermore, IL-10 receptor was shown to be expressed in NK cells. IL-10 alone had a significant effect on NK cytotoxicity which additively increased NK cell cytotoxicity in the presence of IL-15. Neutralizing IL-10 with anti-IL-10 antibody suppressed the inductive effect of IL-10 on NK cell cyto-toxicity; however, IL-10 had no effect on IFN-γ or TNF-α production or NK cell activatory receptor expression. STAT signals are implicated as a key mediator of IL-10/IL-15 cytotoxicity response. Thus, the effect of IL-10 on NK cells is particularly interesting with regard to the STAT3 signal that was enhanced by IL-10 or IL-15.
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KEYWORD
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cytotoxicity, IL-10, IL-15, natural killer cell
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