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KMID : 0578320110320040305
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Molecules and Cells
2011 Volume.32 No. 4 p.305 ~ p.316
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SUMO and SUMOylation in Plants
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Park Hee-Jin
Kim Woe-Yeon
Park Hyeong-Cheol
Lee Sang-Yeol
Hans J. Bohnert
Yun Dae-Jin
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Abstract
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The traditional focus on the central dogma of molecular biology, from gene through RNA to protein, has now been replaced by the recognition of an additional mechanism. The new regulatory mechanism, post-translational modifications to proteins, can actively alter protein function or activity introducing additional levels of functional complexity by altering cellular and sub-cellular location, protein interactions and the outcome of biochemical reaction chains. Modifications by ubiquitin (Ub) and ubiquitin-like modifiers systems are conserved in all eukaryotic organisms. One of them, small ubiquitin-like modifier (SUMO) is present in plants. The SUMO mechanism includes several isoforms of proteins that are involved in reactions of sumoylation and de-sumoylation. Sumoylation affects several important processes in plants. Outstanding among those are responses to environmental stresses. These may be abiotic stresses, such as phosphate deficiency, heat, low temperature, and drought, or biotic stressses, as well including de-fense reactions to pathogen infection. Also, the regula-tions of flowering time, cell growth and develop-ment, and nitrogen assimilation have recently been added to this list. Identification of SUMO targets is material to characterize the function of sumoylation or desumoylation. Affinity purification and mass spectrometric identification have been done lately in plants. Further SUMO non-covalent binding appears to have function in other model organisms and SUMO interacting proteins in plants will be of interest to plant biologists who dissect the dynamic function of SUMO. This review will discuss results of recent insights into the role of sumoylation in plants.
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KEYWORD
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Arabidopsis, SUMO, sumoylation
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