|
KMID : 0578320110320060571
|
|
Molecules and Cells
2011 Volume.32 No. 6 p.571 ~ p.577
|
|
|
Time-Dependent Changes in Lipid Metabolism in Mice with Methionine Choline Deficiency-Induced Fatty Liver Disease
|
|
Park Han-Sol
Jeon Byeong-Hwan
Woo Sung-Hoon
Leem Jae-Chan
Jang Jung-Eun
Cho Min-Sock
Park In-Sun
Lee Ki-Up
Koh Eun-Hee
|
|
|
Abstract
|
|
|
|
Methionine and choline-deficient diet (MCD)-induced fatty liver is one of the best-studied animal models of fatty liver disease. The present study was performed to clarify the relative contributions of individual lipid metabolic pathways to the pathogenesis of MCD-induced fatty liver. Hepatic lipogenesis mediated by the sterol regulatory element-binding protein (SREBP-1c) was increased at 1 week, but not at 6 weeks, of MCD feeding. On the other hand, 14C-palmitate oxidation did not change at 1 week, but significantly decreased at 6 weeks. This decrease was associated with increased expression of fatty acid translocase, a key enzyme involved in fatty acid uptake. Expression of endoplasmic reticulum stress markers was increased in mice given MCD for both 1 and 6 weeks. These findings suggest the presence of time-dependent differences in lipid metabolism in MCD-induced fatty liver disease: SREBP-1c-mediated lipogenesis is important in the early stages of fatty liver disease, whereas increased fatty acid uptake and decreased fatty acid oxidation become more important in the later stages.
|
|
|
KEYWORD
|
|
|
endoplasmic reticulum stress, fatty acid oxidation, lipogenesis, non-alcholic fatty liver disease, sterol regulatory element binding protein-1c
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|