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KMID : 0578320120330010071
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Molecules and Cells
2012 Volume.33 No. 1 p.71 ~ p.77
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Selection and Characterization of Tenascin C Targeting Peptide
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Kim Mee-Young
Kim Ok-Ran
Choi Yong-Seok
Lee Heui-Ran
Park Kee-Rang
Lee Choon-Taek
Kang Keon-Wook
Jeong Sun-Joo
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Abstract
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Since tenascin C is a factor expressed highly in the tu-mor-associated matrix, it would be a desirable first step for targeting the tumor-specific microenvironment. In fact, a high level of tenascin C expression has been re-ported in most solid tumors, including lung cancer, colon cancer and glioblastoma. Therefore, the targeted binding of tenascin C in tumor stroma would inhibit tumor metastasis by modulating cancer cell growth and migration. We isolated a peptide that bound to tenascin C by phage display peptide library selection, and the selected peptide specifically recognized tenascin C protein in xenograft mouse tissue. We also observed exclusive staining of tenascin C by the selected peptide in tumor patient tissues. Moreover, the peptide reduced tenascin C-induced cell rounding and migration. We propose that the tenascin C targeting peptide may be useful as a specific anti-cancer diagnostic and therapeutic tool for most human solid tumors.
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KEYWORD
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anti-cancer therapeutic, peptide, tenascin C
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