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KMID : 0578320120330020105
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Molecules and Cells
2012 Volume.33 No. 2 p.105 ~ p.110
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Molecular Links between Mitochondrial Dysfunctions and Schizophrenia
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Park Ca-Na
Park Sang-Ki
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Abstract
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Schizophrenia is a complex neuropsychiatric disorder with both neurochemical and neurodevelopmental com-ponents in the pathogenesis. Growing pieces of evidence indicate that schizophrenia has pathological components that can be attributable to the abnormalities of mitochondrial function, which is supported by the recent finding suggesting mitochondrial roles for Disrupted-in-Schizophrenia 1 (DISC1). In this minireview, we briefly summarize the current un-derstanding of the molecular links between mitochondrial dysfunctions and the pathogenesis of schizophrenia, covering recent findings from human genetics, functional genomics, proteomics, and molecular and cell biological approaches.
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KEYWORD
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DISC1, mitochondrial dysfunctions, Schizophrenia
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