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KMID : 0578320120330030259
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Molecules and Cells
2012 Volume.33 No. 3 p.259 ~ p.267
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CD99-Dependent Expansion of Myeloid-Derived Suppressor Cells and Attenuation of Graft-Versus-Host Disease
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Park Hyo-Jin
Byun Da-Hye
Lee An-Hi
Kim Ju-Hyun
Ban Young-Larn
Masatake Araki
Kimi Araki
Ken-ichi Yamamura
Kim In-Ho
Park Seong-Hoe
Jung Kyeong-Cheon
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Abstract
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CD99 is involved in many cellular events, such as the generation of Hodgkin and Reed-Sternberg cells, T cell co-stimulation, and leukocyte transendothelial migration. However, these studies have been limited to in vitro or in vivo experiments using CD99-deficient cell lines or anti-CD99 antibodies. In the present study, using CD99-deficient mice established by the exchangeable gene trap method, we investigated the physiologic function of murine CD99. In a B6 splenocytes ? bm12 graft-versus-host disease model, wild-type cells were minimally lethal, whereas all mice that received CD99-deficient donor cells developed an early and more severe pathology. Graft-versus-host disease in these mice was associated with insufficient expansion of myeloid-derived suppressor cells. This was confirmed by experiments illustrating that the injection of wild-type donor cells depleted of Mac-1+ cells led to an almost identical disease course as the CD99-deficient donor system. Therefore, these results suggest that CD99 plays a crucial role in the attenuation of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells.
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KEYWORD
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CD99, graft versus host disease, myeloid cells
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