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KMID : 0578320120330030269
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Molecules and Cells
2012 Volume.33 No. 3 p.269 ~ p.275
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Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
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Lee Si-Chul
Kim You-Sun
Jeon Un-Sil
Kim Yoon-Keun
Jan K. Schjoerring
An Gyn-Heung
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Abstract
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Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. By increasing the expression of nicotianamine synthase (NAS), we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression.
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KEYWORD
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anemia, bioavailability, mouse, rice
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