|
KMID : 0578320120340010035
|
|
Molecules and Cells
2012 Volume.34 No. 1 p.35 ~ p.41
|
|
|
Tenascin-C Produced by Oxidized LDL-Stimulated Macrophages Increases Foam Cell Formation through Toll-like Receptor-4
|
|
Rui Liu
Yong He
Li Bo
Jun Liu
Yingang Ren
Wei Han
Xing Wang
Lihua Zhang
|
|
|
Abstract
|
|
|
|
Atherosclerosis is a chronic inflammatory disease in which both innate and adaptive immunity are involved. Although there have been major advances in the involve-ment of toll-like receptor 4 (TLR4) and CD36 in the initiation and development of this disease, detailed mechanisms remain unknown. Here, we show that tenascin-C (TN-C) can stimulate foam cell formation and this can be inhibited by a TLR4-blocking antibody or CD36 gene silencing. Our results identify TN-C-TLR4 activation as a common molecular mechanism in oxLDL-stimulated foam cell formation and atherosclerosis. In addition, CD36 is the major scavenger receptor responsible for the TN-C-mediated foam cell formation. Taken together, we have identified that TN-C produced by oxLDL-stimulated macrophages increases foam cell formation through TLR4 and scavenger receptor CD36.
|
|
|
KEYWORD
|
|
|
atherosclerosis, CD36, foam cell formation, tenascin-c, toll-like receptor 4
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|