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KMID : 0578320130350010017
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Molecules and Cells
2013 Volume.35 No. 1 p.17 ~ p.24
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MicroRNA-205 Directly Regulates the Tumor Suppressor, Interleukin-24, in Human KB Oral Cancer Cells
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Kim Jae-Sung
Yu Sun-Kyoung
Lee Myoung-Hwa
Park Min-Gyeong
Park Eu-Teum
Kim Su-Gwan
Lee Sook-Young
Kim Chun-Sung
Kim Heung-Joong
Chun Hong-Sung
Chun Sang-Woo
Kim Do-Kyung
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Abstract
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MicroRNA (miRNA) is a form of small noncoding RNA that regulates the expression of genes either by inhibiting
mRNA translation or by inducing its degradation. Small microRNA play important roles in regulating a large number
of cellular processes, including development, proliferation and apoptosis. This study examined the biological
functions of miR-205 as a tumor suppressor in KB oral cancer cells. The results showed that miR-205 expression
was significantly lower in KB oral cancer cells than in human normal oral keratinocytes. Furthermore, the miR-205
over-expressed in KB oral cancer cells increased the cell cytotoxicity and induced apoptosis through the activation
of caspase-3/-7. The transfection of miR-205 into KB oral cancer cells strongly induced IL-24, a well known cytokine
that acts as a tumor suppressor in a range of tumor tissues. In addition, miR-205 targeted the IL-24 promoter directly
to induce gene expression. Overall, miR-205 has significant therapeutic potential to turn on silenced tumor
suppressor genes by targeting them with miRNA.
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KEYWORD
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apoptosis, human oral cancer, interleukin-24, microRNA-205
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