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KMID : 0578320130350040269
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Molecules and Cells
2013 Volume.35 No. 4 p.269 ~ p.273
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A New Helicase Assay Based on Graphene Oxide for Anti-Viral Drug Development
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Jang Hong-Je
Ryoo Soo-Ryoon
Lee Min-Jae
Han Sang-Woo
Min Dal-Hee
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Abstract
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Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high potential in many research areas, including applications as a biosensor and drug delivery vehicle. Various GO-based biosensors have been developed, largely based on its surface adsorption properties for detecting biomolecules, such as nucleotides and peptides, and real-time monitoring of enzymatic reactions. In this review, we discuss recent advances in GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed in high-throughput screening to discover selective helicase inhibitors.
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KEYWORD
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biosensor, drug screening, graphene oxide, helicase, hepatitis C
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