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KMID : 0578320130350040274
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Molecules and Cells
2013 Volume.35 No. 4 p.274 ~ p.284
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Magnetic Nanoparticles for Multi-Imaging and Drug Delivery
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Lee Jae-Hyun
Kim Ji-Wook
Cheon Jin-Woo
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Abstract
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Various bio-medical applications of magnetic nanoparti-cles have been explored during the past few decades. As tools that hold great potential for advancing biological sciences, magnetic nanoparticles have been used as platform materials for enhanced magnetic resonance imaging (MRI) agents, biological separation and magnetic drug delivery systems, and magnetic hyperthermia treatment. Furthermore, approaches that integrate various imaging and bioactive moieties have been used in the design of multi-modality systems, which possess synergistically en-hanced properties such as better imaging resolution and sensitivity, molecular recognition capabilities, stimulus responsive drug delivery with on-demand control, and spatio-temporally controlled cell signal activation. Below, recent studies that focus on the design and synthesis of multi-mode magnetic nanoparticles will be briefly reviewed and their potential applications in the imaging and therapy areas will be also discussed.
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KEYWORD
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magnetic drug delivery, magnetic hyperthermia, magnetic nanoparticle, magnetic resonance imaging, multi-mode imaging
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