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KMID : 0578320130350060550
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Molecules and Cells
2013 Volume.35 No. 6 p.550 ~ p.556
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Angiopoietin-1 Elicits Pro-Inflammatory Responses in Monocytes and Differentiating Macrophages
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Seok Seung-Hyeok
Heo Jong-Ik
Hwang Ji-Hye
Na Yi-Rang
Yun Jang-Hyuk
Lee Eun-Hui
Park Jong-Wan
Cho Chung-Hyun
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Abstract
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The angiopoietin/Tie2 system is an important regulator of angiogenesis and inflammation. In addition to its functions in endothelial cells, Tie2 expression on non-endothelial cells allows for angiopoietin ligands to stimulate the cells. Although Ang1 is a strong Tie2 receptor agonist, little is known regarding the effect of Ang1 on non-endothelial cells, such as monocytes and macrophages. In this study, we found that Ang1 functionally binds to and stimulates monocytes via p38 and Erk1/2 phosphorylation. Ang1-mediated monocyte stimulation is associated with proinflammatory cytokine TNF-α expression. We also determined that Ang1 switched macrophage differentiation toward a pro-inflammatory phenotype, even in the presence of an anti-inflammatory mediator. These findings suggest that Ang1 plays a role in stimulating pro-inflammatory responses and could provide a new strategy by which to manage inflammatory responses.
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KEYWORD
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angiopoietin, inflammation, macrophage, monocyte, Tie2
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