KMID : 0578320130360020099
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Molecules and Cells 2013 Volume.36 No. 2 p.99 ~ p.104
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NMDA Receptor as a Newly Identified Member of the Metabotropic Glutamate Receptor Family: Clinical Implications for Neurodegenerative Diseases
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Chung Chi-Hye
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Abstract
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Recent reports have proposed a novel function for the Nmethyl-D-aspartate (NMDA) receptor (NMDAR), a well-known excitatory, ionotropic receptor. A series of observations employing pharmacological techniques has proposed that upon ligand binding, this ionotropic receptor can actually function via signaling cascades independent of traditional ionotropic action. Moreover, the ¡°metabotropic¡± action of NMDARs is suggested to mediate a form of synaptic plasticity, namely long-term synaptic depression (LTD), which shares cellular mechanisms with the synaptic deficits observed in Alzheimer¡¯s disease. Given that a growing body of clinical and preclinical evidence strongly recommends NMDAR antagonists for their therapeutic potentials and advantages in a variety of diseases, further investigation into their molecular and cellular mechanisms is required to better understand the ¡°metabotropic¡± action of NMDARs.
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KEYWORD
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Alzheimer¡¯s disease, glutamate receptors, ionotropic, long term depression, metabotropic, synaptic plasticity
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