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KMID : 0578320130360050472
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Molecules and Cells
2013 Volume.36 No. 5 p.472 ~ p.475
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EPITRANS: A Database that Integrates Epigenome and Transcriptome Data
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Cho Soo-Young
Chai Jin-Choul
Park Soo-Jun
Seo Hye-Myung
Sohn Chae-Bong
Lee Young-Seek
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Abstract
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Epigenetic modifications affect gene expression and thereby govern a wide range of biological processes such as differentiation, development and tumorigenesis. Recent initiatives to define genome-wide DNA methy-lation and histone modification profiles by microarray and sequencing methods have led to the construction of databases. These databases are repositories for international epigenetic consortiums or provide mining results from PubMed, but do not integrate the epigenetic information with gene expression changes. In order to overcome this limitation, we constructed EPITRANS, a novel database that visualizes the relationships between gene expression and epigenetic modifications. EPITRANS uses combined analysis of epigenetic modification and gene expression to search for cell function-related epigenetic and transcriptomic al-terations (Freely available on the web at http://epitrans.org).
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KEYWORD
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database, epigenome, transcriptome
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