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KMID : 0578320140370010051
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Molecules and Cells
2014 Volume.37 No. 1 p.51 ~ p.57
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Nucleolar GTPase NOG-1 Regulates Development, Fat Storage, and Longevity through Insulin/IGF Signaling in
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Kim Young-Il
Jaya Bandyopadhyay
Cho In-Jeong
Lee Ju-Yeon
Park Dae-Ho
Cho Jeong-Hoon
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Abstract
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NOG1 is a nucleolar GTPase that is critical for 60S ribosome biogenesis. Recently, NOG1 was identified as one of the downstream regulators of target of rapamycin (TOR) in yeast. It is reported that TOR is involved in regulating lifespan and fat storage in . Here, we show that the ortholog (T07A9.9: ) in regulates growth, development, lifespan, and fat metabolism. A green fluorescence protein (GFP) promoter assay revealed ubiquitous expression of from the early embryonic to the adult stage. Furthermore, the GFP-tagged NOG-1 protein is localized to the nucleus, whereas the aberrant NOG-1 protein is concentrated in the nucleolus. Functional studies of NOG-1 in further revealed that knockdown resulted in smaller broodsize, slower growth, increased life span, and more fat storage. Moreover, over-expression resulted in decreased life span. Taken together, our data suggest that in may be an important player in regulating life span and fat storage the insulin/IGF pathway.
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KEYWORD
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Array, Array, Array, fat metabolism, insulin/IGF-1, life span, NOG-1, Array, nucleolar GTPase, Array
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