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KMID : 0578320140370040337
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Molecules and Cells
2014 Volume.37 No. 4 p.337 ~ p.344
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Down-Regulation of Sox11 Is Required for Efficient Osteogenic Differentiation of Adipose-Derived Stem Cells
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Choi Mi-Kyung
Seong Ik-Joo
Kang Seon-Ah
Kim Jae-Sang
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Abstract
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Adipose-derived stem cells represent a type of mesenchymal stem cells with the attendant capacity to self-renew and differentiate into multiple cell lineages. We have performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. Functional assays demonstrate that down-regulation of Sox11 is required for an efficient differentiation. Furthermore, results from forced expression of constitutively-active and dominant-negative derivatives of Sox11 indicate that Sox11 functions as a transcriptional activator in inhibiting osteogenesis. Sox11 thus represents a novel regulator of osteogenesis whose expression and activity can be potentially manipulated for controlled differentiation.
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KEYWORD
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adipose-derived stem cell, differentiation, mesenchymal stem cell, osteogenesis, Sox11
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