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KMID : 0578320140370120841
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Molecules and Cells
2014 Volume.37 No. 12 p.841 ~ p.850
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Polycomb-Mediated Gene Silencing in Arabidopsis thaliana
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Kim Dong-Hwan
Sung Si-Bum
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Abstract
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Polycomb group (PcG) proteins are conserved chromatin regulators involved in the control of key developmental programs in eukaryotes. They collectively provide the transcriptional memory unique to each cell identity by maintaining transcriptional states of developmental genes. PcG proteins form multi-protein complexes, known as Polycomb repressive complex 1 (PRC1) and Polycomb repressive complex 2 (PRC2). PRC1 and PRC2 contribute to the stable gene silencing in part through catalyzing covalent histone modifications. Components of PRC1 and PRC2 are well conserved from plants to animals. PcG-mediated gene silencing has been extensively investigated in efforts to understand molecular mechanisms underlying developmental programs in eukaryotes. Here, we describe our current knowledge on PcG-mediated gene repression which dictates developmental programs by dynamic layers of regulatory activities, with an emphasis given to the model plant Arabidopsis thaliana.
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KEYWORD
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chromatin looping, epigenetics, gene silencing, polycomb, trithorax
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