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KMID : 0578320150380090759
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Molecules and Cells
2015 Volume.38 No. 9 p.759 ~ p.764
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Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
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Lee Na-Rae
Kim Hye-In
Choi Myung-Soo
Yi Chae-Min
Inn Kyung-Soo
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Abstract
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Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-κB and interferon production. TRIM25 is required for the full activation of NF-κB at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-κB activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-κB.
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KEYWORD
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MAVS, MDA5, NF-κB, TRAF6, TRIM25
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