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KMID : 0578320150380110991
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Molecules and Cells
2015 Volume.38 No. 11 p.991 ~ p.997
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Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin
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Ryu Jin-Hyun
Yoon Nal-Ae
Seong Hye-Min
Jeong Joo-Yeon
Kang Seok-Min
Park Nam-Mi
Choi Jun-Gil
Lee Dong-Hoon
Roh Gu-Seob
Kim Hyun-Joon
Cho Gyeong-Jae
Choi Wan-Sung
Park Jae-Yong
Park Jeong-Woo
Kang Sang-Soo
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Abstract
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Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4′-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3′ untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.
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KEYWORD
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apoptosis, glioma, resveratrol, TTP, uPA, uPAR
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