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KMID : 0578320160390010001
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Molecules and Cells
2016 Volume.39 No. 1 p.1 ~ p.5
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Overview on Peroxiredoxin
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Rhee Sue-Goo
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Abstract
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Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the “peroxidatic” Cys (CP) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the CP-SH to cysteine sulfenic acid (CP?SOH), which then reacts with another cysteine residue, named the “resolving” Cys (CR) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.
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KEYWORD
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circadian rhythm, hydrogen peroxide, peroxiredoxin, redox regulation, thiol-specific peroxidasee
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