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KMID : 0578320160390010053
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Molecules and Cells
2016 Volume.39 No. 1 p.53 ~ p.59
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Distribution and Features of the Six Classes of Peroxiredoxins
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Poole Leslie B.
Nelson Kimberly J.
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Abstract
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Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ∼3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).
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KEYWORD
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active site profiling, bioinformatics, disulfide reductase, peroxide reductase, thiol peroxidase
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