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KMID : 0578320160390010060
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Molecules and Cells
2016 Volume.39 No. 1 p.60 ~ p.64
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Multiple Roles of Peroxiredoxins in Inflammation
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Knoops Bernard
Argyropoulou Vasiliki
Becker Sarah
Ferte Laura
Kuznetsova Oksana
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Abstract
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Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recently, it has been proposed that peroxiredoxins may play key roles in innate immunity and inflammation. Indeed, peroxiredoxins are evolutionarily conserved peroxidases able to reduce, with high rate constants, hydrogen peroxide, alkyl hydroperoxides and peroxynitrite which are generated during inflammation. In this minireview, we point out different possible roles of peroxiredoxins during inflammatory processes such as cytoprotective enzymes against oxidative stress, modulators of redox signaling, and extracellular pathogen- or damage-associated molecular patterns. A better understanding of peroxiredoxin functions in inflammation could lead to the discovery of new therapeutic targets.
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KEYWORD
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inflammation, innate immunity, peroxiredoxins, reactive oxygen species, reactive nitrogen species, redox signaling
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