KMID : 0578320160390020087
|
|
Molecules and Cells 2016 Volume.39 No. 2 p.87 ~ p.95
|
|
Sirt1 and the Mitochondria
|
|
Tang Bor Luen
|
|
Abstract
|
|
|
Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1¡¯s deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1¥á (PGC-1¥á) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1¡¯s role in caloric restriction and impacts on longevity. The notion of Sirt1¡¯s regulation of PGC-1¥á activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1¡¯s regulation of mitochondrial biogenesis and turnover, in relation to PGC-1¥á deacetylation and various aspects of cellular physiology and disease.
|
|
KEYWORD
|
|
mitochondria, mitochondrial biogenesis, mitophagy, PGC-1¥á, Sirt1
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|