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KMID : 0578320160390030169
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Molecules and Cells
2016 Volume.39 No. 3 p.169 ~ p.178
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N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway
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Lee Kang-Eun
Heo Ji-Eun
Kim Jeong-Mok
Hwang Cheol-Sang
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Abstract
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Although Nα-terminal acetylation (Nt-acetylation) is a pervasive protein modification in eukaryotes, its general functions in a majority of proteins are poorly understood. In 2010, it was discovered that Nt-acetylation creates a specific protein degradation signal that is targeted by a new class of the N-end rule proteolytic system, called the Ac/N-end rule pathway. Here, we review recent advances in our understanding of the mechanism and biological functions of the Ac/N-end rule pathway, and its crosstalk with the Arg/N-end rule pathway (the classical N-end rule pathway).
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KEYWORD
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degron, N-end rule, N-terminal acetylation, proteolysis, ubiquitin
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