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KMID : 0578320160390040292
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Molecules and Cells
2016 Volume.39 No. 4 p.292 ~ p.298
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Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c
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Jiang Yong
Liu He
Liu Wen Jing
Chen Chang Jun
Lin Fu Gui
Zhuo Yan Hang
Qian Xiao Zhen
Wang Zeng Bin
Wang Yu
Zhang Peng
Jia Hong Liang
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Abstract
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Aquaporin 1 (AQP1) is expressed in most microvasculature endothelial cells and forms water channels that play major roles in a variety of physiologic processes. This study aimed to delineate the transcriptional regulation of AQP1 by Mef2c in endothelial cells. Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells (HUVEC). Over-expression of Mef2c, Sp1, or Mef2c/Sp1 increased HUVEC migration and tube-forming ability, which can be abolished AQP1 knockdown. These data indicate that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells.
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KEYWORD
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angiogenesis, AQP1, Mef2c, migration, vascular tube formation
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