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KMID : 0578320160390070515
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Molecules and Cells
2016 Volume.39 No. 7 p.515 ~ p.523
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The Role of Lymphatic Niches in T Cell Differentiation
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Capece Tara
Kim Min-Soo
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Abstract
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Long-term immunity to many viral and bacterial pathogens requires CD8+ memory T cell development, and the induction of long-lasting CD8+ memory T cells from a na?ve, undifferentiated state is a major goal of vaccine design. Formation of the memory CD8+ T cell compartment is highly dependent on the early activation cues received by na?ve CD8+ T cells during primary infection. This review aims to highlight the cellularity of various niches within the lymph node and emphasize recent evidence suggesting that distinct types of T cell activation and differentiation occur within different immune contexts in lymphoid organs.
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KEYWORD
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CD8 T cell, chemokine, immune memory, lymph node, T cell
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