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KMID : 0578320160390070573
Molecules and Cells
2016 Volume.39 No. 7 p.573 ~ p.579
A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster
Lee Hyun-Jin

Choi Hyun-Woo
Zhang Chen
Park Zee-Yong
Kim Young-Joon
Abstract
During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating. We identify two CG3542-ppk expressing neurons that innervate the upper oviduct and appear to be responsible for normal egg-laying. Our results suggest specific subsets of the ppk neurons are responsible for each PMR component.
KEYWORD
CG3542, egg-laying, phosphoprotein, pickpocket, post mating response, sex peptide
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