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KMID : 0578320160390080603
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Molecules and Cells
2016 Volume.39 No. 8 p.603 ~ p.610
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Impaired Memory in OT-II Transgenic Mice Is Associated with Decreased Adult Hippocampal Neurogenesis Possibly Induced by Alteration in Th2 Cytokine Levels
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Jeon Seong-Gak
Kim Kyoung-Ah
Chung Hyun-Ju
Choi Jung-Hyun
Song Eun-Ji
Han Seung-Yun
Oh Myung-Sook
Park Jong-Hwan
Kim Jin-Il
Moon Min-Ho
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Abstract
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Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. However, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.
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KEYWORD
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adult neurogenesis, CD4 T cells, cognition, OT-II transgenic mice, Th2 cytokines
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