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KMID : 0578320160390120855
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Molecules and Cells
2016 Volume.39 No. 12 p.855 ~ p.861
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Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model
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Park Chan-Mi
Kim Hye-Min
Kim Dong-Hyun
Han Ho-Jin
Noh Ha-Neul
Jang Jae-Hyuk
Park Soo-Hyun
Chae Han-Jung
Chae Soo-Wan
Ryu Eun-Kyoung
Lee Sang-Ku
Liu Kang Dong
Liu Hai Dan
Ahn Jong-Seog
Kim Young-Ock
Kim Bo-Yeon
Soung Nak-Kyun
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Abstract
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Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the preventive effects of ginsenoside Re against osteoclast differentiation are not known. We studied the effect of ginsenoside Re on osteoclast differentiation, RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity, and formation of multinucleated osteoclasts in vitro. Ginsenoside Re hampered osteoclast differentiation in a dose-dependent manner. In an in vivo zebrafish model, aqueous ginseng extract and ginsenoside Re had anti-osteoclastogenesis effects. These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health.
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KEYWORD
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ginsenoside Re, osteoclasts, RANKL, zebrafish
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