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KMID : 0578320170400010001
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Molecules and Cells
2017 Volume.40 No. 1 p.1 ~ p.9
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SR Proteins: Binders, Regulators, and Connectors of RNA
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Jeong Sun-Joo
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Abstract
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Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.
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KEYWORD
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export, RNA-binding proteins, SR proteins, splicing, transcription, translation
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