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KMID : 0578320170400060434
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Molecules and Cells
2017 Volume.40 No. 6 p.434 ~ p.439
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Gestational Diabetes Affects the Growth and Functions of Perivascular Stem Cells
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An Bo-Rim
Kim Eun-Bi
Song Haeng-Seok
Ha Kwon-Soo
Han Eun-Taek
Park Won-Sun
Ahn Tae-Gyu
Yang Se-Ran
Na Sung-Hun
Hong Seok-Ho
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Abstract
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Gestational diabetes mellitus (GDM), one of the common metabolic disorders of pregnancy, leads to functional alterations in various cells including stem cells as well as some abnormalities in fetal development. Perivascular stem cells (PVCs) have gained more attention in recent years, for the treatment of various diseases. However, the effect of GDM on PVC function has not been investigated. In our study, we isolated PVCs from umbilical cord of normal pregnant women and GDM patients and compared their phenotypes and function. There is no significant difference in phenotypic expression, response to bFGF exposure and adipogenic differentiation capacity between normal (N)-PVCs and GDM-PVCs. However, when compared with N-PVCs, early passage GDM-PVCs displayed decreased initial rates of cell yield and proliferation as well as a reduced ability to promote wound closure. These results suggest that maternal metabolic dysregulation during gestation can alter the function of endogenous multipotent stem cells, which may impact their therapeutic effectiveness.
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KEYWORD
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differentiation, gestational diabetes mellitus, peri-vascular stem cells, proliferation
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