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KMID : 0578320180410020083
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Molecules and Cells
2018 Volume.41 No. 2 p.83 ~ p.92
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The Role of Hippo Pathway in Cancer Stem Cell Biology
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Park Jae-Hyung
Shin Ji-Eun
Park Hyun-Woo
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Abstract
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The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.
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KEYWORD
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cancer stem cell, Hippo pathway, metastasis, YAP/TAZ
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