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KMID : 0578320180410040257
Molecules and Cells
2018 Volume.41 No. 4 p.257 ~ p.263
Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye
Moon Kyeong-Hwan

Kim Jin-Woo
Abstract
Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues. In this review, we summarize recent studies that have explored the relationship between the Hippo signaling pathway and growth of optic neuroepithelial compartments. We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit.
KEYWORD
ciliary margin, eye development, Hippo pathway, neurofibromin 2 (NF2), retina
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