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KMID : 0578320180410050373
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Molecules and Cells
2018 Volume.41 No. 5 p.373 ~ p.380
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Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
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Park Dong-Seok
Bae Sung-Won
Yoon Taek-Han
Ko Jae-Won
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Abstract
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Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present mini-review, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum.
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KEYWORD
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brain disorder, neural circuit, specificity, synapse, synaptic adhesion
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