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KMID : 0578320180410070622
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Molecules and Cells
2018 Volume.41 No. 7 p.622 ~ p.630
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Structural Basis for LAR-RPTP?Mediated Synaptogenesis
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Won Seoung-Youn
Kim Ho-Min
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Abstract
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Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP?mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clustering of LARRPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP?mediated synaptogenesis.
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KEYWORD
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heparan sulfate, higher-order clustering, LARRPTPs, LAR-RPTP?mediated trans-synaptic adhesion complex, synaptic adhesion molecules
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