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KMID : 0578320180410070684
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Molecules and Cells
2018 Volume.41 No. 7 p.684 ~ p.694
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Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members
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Jin Young
You Long
Kim Hye-Jeong
Lee Han-Woong
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Abstract
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Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3- only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and antiapoptotic proteins. Although the detailed mechanisms underlying the hTERT BH3-like motif functions and interactions between hTERT and BCL-2 family proteins have not been elucidated, this work proposes a possible connection between hTERT and BCL-2 family members and reconsiders the role of the BH3-like motif as an interaction motif.
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KEYWORD
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apoptosis, BH3-like motif, BCL-2 family proteins, hTERT
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