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KMID : 0578320190420110747
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Molecules and Cells
2019 Volume.42 No. 11 p.747 ~ p.754
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Cellular and Molecular Links between Autoimmunity and Lipid Metabolism
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Ryu Hee-Ju
Kim Ji-Yeon
Kim Dae-Hong
Lee Jeong-Eun
Chung Yeon-Seok
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Abstract
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The incidence of atherosclerosis is higher among patients with several autoimmune diseases such as psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is well documented that innate immune cells including macrophages and dendritic cells sense lipid species such as saturated fatty acids and oxidized low-density lipoprotein and produce pro-inflammatory cytokines and chemokines. However, whether a hyperlipidemic environment also impacts autoimmune T cell responses has been unclear. Among CD4+ T cells, Th17 and follicular helper T (Tfh) cells are known to play pathogenic roles in the development of hyperlipidemiaassociated autoimmune diseases. This review gives an overview of the cellular and molecular mechanisms by which dysregulated lipid metabolism impacts the pathogenesis of autoimmune diseases, with specific emphasis on Th17 and Tfh cells.
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KEYWORD
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autoimmune diseases, hyperlipidemia, lipid metabolism, Tfh cell, Th17 cell
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