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KMID : 0578320210440100699
Molecules and Cells
2021 Volume.44 No. 10 p.699 ~ p.705
Generation and Fates of Supernumerary Centrioles in Dividing Cells
Shin Byung-Ho

Kim Myung-Se
Lee Ye-Joo
Jung Gee-In
Rhee Kun-Soo
Abstract
The centrosome is a subcellular organelle from which a cilium assembles. Since centrosomes function as spindle poles during mitosis, they have to be present as a pair in a cell. How the correct number of centrosomes is maintained in a cell has been a major issue in the fields of cell cycle and cancer biology. Centrioles, the core of centrosomes, assemble and segregate in close connection to the cell cycle. Abnormalities in centriole numbers are attributed to decoupling from cell cycle regulation. Interestingly, supernumerary centrioles are commonly observed in cancer cells. In this review, we discuss how supernumerary centrioles are generated in diverse cellular conditions. We also discuss how the cells cope with supernumerary centrioles during the cell cycle.
KEYWORD
cancer cells, cell cycle, centrosome, mitosis, supernumerary centrioles
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